The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance

Abstract Background The dynamics of histone post-translational modifications (PTMs) are sparsely Countertop Steamers described, especially in their true physiological context of proteoforms (single histone molecules harboring combinations of PTMs).Methods Here we time-resolve the response of cells to SUV4-20 methyltransferase inhibition and unbiase

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Sector-Based Detection for Hands-Free Speech Enhancement in Cars

Adaptation control of beamforming interference cancellation techniques is investigated for in-car speech acquisition.Two efficient adaptation control methods are proposed that avoid target cancellation.The "implicit" method varies the step-size continuously, Buddy Stirrups based on the filtered output signal.The "explicit" method decides in a bina

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